The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A | Zendy

Muhammad Ishfaq | Zendy; Kazuhiro Maeta | Zendy; Satoko Maeda | Zendy; Tohru Natsume | Zendy; Akihiro Ito | Zendy; Minoru Yoshida | Zendy

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The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Author(s) -

Muhammad Ishfaq,

Kazuhiro Maeta,

Satoko Maeda,

Tohru Natsume,

Akihiro Ito,

Minoru Yoshida

Publication year - 2012

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120620

Subject(s) - acetylation , gene isoform , eukaryotic translation , subcellular localization , lysine , sirt2 , eukaryotic initiation factor , initiation factor , translation (biology) , biology , microbiology and biotechnology , chemistry , biochemistry , messenger rna , gene , sirtuin , amino acid

Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. Here we report that eIF5A2 is reversibly acetylated at lysine-47. HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2.

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