Inhibitory Effect of Ellagitannin Metabolites on IgE-Mediated Allergic Responses in RBL-2H3 Cells | Zendy

Takao Nagano | Zendy; Hideyuki Ito | Zendy; Takeaki Okamoto | Zendy

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Inhibitory Effect of Ellagitannin Metabolites on IgE-Mediated Allergic Responses in RBL-2H3 Cells

Author(s) -

Takao Nagano,

Hideyuki Ito,

Takeaki Okamoto

Publication year - 2012

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120448

Subject(s) - ellagic acid , ellagitannin , degranulation , tumor necrosis factor alpha , chemistry , immunoglobulin e , secretion , antigen , allergic response , immunopharmacology , basophilic , antibody , biochemistry , microbiology and biotechnology , immunology , immune system , biology , medicine , polyphenol , receptor , pathology , antioxidant

The effects of four ellagitannin metabolites (M1-M4) and ellagic acid on immunoglobulin E-mediated allergic responses in rat basophilic leukemia-2H3 cells were investigated. M1-M4 inhibited the antigen-induced degranulation and secretion of interleukin-4 and tumor necrosis factor-α, but ellagic acid only slightly did so under the same experimental conditions. M1 inhibited the activation of the mitogen-activated protein kinases in antigen-stimulated cells.

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