Identification and Biological Activities of Bryostatins from Japanese Bryozoan | Zendy

Sayo Ueno | Zendy; Ryo C. Yanagita | Zendy; Kazuma Murakami | Zendy; Akira Murakami | Zendy; Harukuni Tokuda | Zendy; Nobutaka Suzuki | Zendy; Takeshi Fujiwara | Zendy; Kazuhiro Irie | Zendy

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Identification and Biological Activities of Bryostatins from Japanese Bryozoan

Author(s) -

Sayo Ueno,

Ryo C. Yanagita,

Kazuma Murakami,

Akira Murakami,

Harukuni Tokuda,

Nobutaka Suzuki,

Takeshi Fujiwara,

Kazuhiro Irie

Publication year - 2012

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120026

Subject(s) - biology , protein kinase c , identification (biology) , computational biology , kinase , microbiology and biotechnology , ecology

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

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