Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared fromCaulerpa lentillifera | Zendy

Reiko MAEDA | Zendy; Tomoaki Ida | Zendy; Hideshi Ihara | Zendy; Tatsuji Sakamoto | Zendy

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Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared fromCaulerpa lentillifera

Author(s) -

Reiko MAEDA,

Tomoaki Ida,

Hideshi Ihara,

Tatsuji Sakamoto

Publication year - 2012

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120016

Subject(s) - mcf 7 , apoptosis , chemistry , poly adp ribose polymerase , hydrolysis , biochemistry , polymerase , cancer cell , cancer , enzyme , biology , human breast , genetics

β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.

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