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The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.

New Rapid Screening Method for Anti-Aging Compounds Using Budding Yeast and Identification of Beauveriolide I as a Potent Active Compound