New Rapid Screening Method for Anti-Aging Compounds Using Budding Yeast and Identification of Beauveriolide I as a Potent Active Compound | Zendy

Shigeru Nakaya | Zendy; Saki Mizuno | Zendy; Hiroki Ishigami | Zendy; Yasuhiro Yamakawa | Zendy; Hirokazu Kawagishi | Zendy; Takashi Ushimaru | Zendy

Open Access

New Rapid Screening Method for Anti-Aging Compounds Using Budding Yeast and Identification of Beauveriolide I as a Potent Active Compound

Author(s) -

Shigeru Nakaya,

Saki Mizuno,

Hiroki Ishigami,

Yasuhiro Yamakawa,

Hirokazu Kawagishi,

Takashi Ushimaru

Publication year - 2012

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.110872

Subject(s) - budding yeast , yeast , cls upper limits , budding , mitosis , saccharomyces cerevisiae , active compound , identification (biology) , biology , chemistry , microbiology and biotechnology , computational biology , biochemistry , combinatorial chemistry , botany , medicine , optometry

The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.

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