LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis | Zendy

Yasuaki Mohri | Zendy; Kazunori Oyama | Zendy; Mizuki Sone | Zendy; Atsushi Akamatsu | Zendy; Katsuhiko Nishimori | Zendy

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LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis

Author(s) -

Yasuaki Mohri,

Kazunori Oyama,

Mizuki Sone,

Atsushi Akamatsu,

Katsuhiko Nishimori

Publication year - 2012

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.110834

Subject(s) - mesenchyme , embryonic stem cell , kidney development , biology , kidney , apoptosis , medicine , endocrinology , embryo , microbiology and biotechnology , gene , genetics

In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development, we performed an analysis of kidneys in Lgr4-/- embryos. We stained Lgr4-/- kidneys with anti-WT1 and anti-Cleaved Caspase3 antibodies at E16.5, and observed that the structures of the cap mesenchyme were disrupted and that apoptosis increased. In addition, the expression of PAX2, an anti-apoptotic factor in kidney development, was also significantly decreased at E16.5. We found that the LGR4 defect caused an increase in apoptosis in the peripheral mesenchyme during kidney development.

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