Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells | Zendy

Yoshimi Yamakami | Zendy; Kensuke Miki | Zendy; Morio Endoh | Zendy; Ryuzo Yonekura | Zendy; Ryo Ukekawa | Zendy; Yusuke Kobayashi | Zendy; Michihiko Fujii | Zendy; Dai Ayusawa | Zendy

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Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells

Author(s) -

Yoshimi Yamakami,

Kensuke Miki,

Morio Endoh,

Ryuzo Yonekura,

Ryo Ukekawa,

Yusuke Kobayashi,

Michihiko Fujii,

Dai Ayusawa

Publication year - 2011

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.110179

Subject(s) - cytotoxicity , senescence , chemistry , cell culture , pulmonary surfactant , microbiology and biotechnology , in vitro , biology , biochemistry , genetics

We evaluated the cytotoxicity of surfactants in human cells. Synthetic surfactants showed different cytotoxicity levels depending on their structures. The cytotoxicity of commercial washing products was determined mainly by the contents of surfactants. All of them induced premature senescence in normal cells, but not in tumor-derived or immortalized cells, under sublethal conditions. Residual surfactants might be a risk factor for skin aging.

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