Neuroprotective Kaurane Diterpenes fromFritillaria ebeiensis | Zendy

Jing Xu | Zendy; Ping Guo | Zendy; Cuizhou Liu | Zendy; Zhanping Sun | Zendy; Liping Gui | Zendy; Yuanqiang Guo | Zendy; Tohru Yamakuni | Zendy; Yasushi Ohizumi | Zendy

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Neuroprotective Kaurane Diterpenes fromFritillaria ebeiensis

Author(s) -

Jing Xu,

Ping Guo,

Cuizhou Liu,

Zhanping Sun,

Liping Gui,

Yuanqiang Guo,

Tohru Yamakuni,

Yasushi Ohizumi

Publication year - 2011

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.110146

Subject(s) - diterpene , neuroprotection , stereochemistry , chemistry , biology , pharmacology

The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

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