Prevention of Oxidative DNA Degradation by Copper-Binding Peptides | Zendy

Ken Yokawa | Zendy; Tomoko Kagenishi | Zendy; Tomonori Kawano | Zendy

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Prevention of Oxidative DNA Degradation by Copper-Binding Peptides

Author(s) -

Ken Yokawa,

Tomoko Kagenishi,

Tomonori Kawano

Publication year - 2011

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100900

Subject(s) - ascorbic acid , tripeptide , hydrogen peroxide , chemistry , radical , dna , divalent , hydroxyl radical , dna damage , copper , biochemistry , peptide , organic chemistry , food science

Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid.

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