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Suppression of Oral Tolerance byLactococcus lactisin Mice
Author(s) -
Tohru Sakai,
Yuko Hirota,
Mariko Nakamoto,
Emi Shuto,
Toshio Hosaka,
Seiya Makino,
Shuji Ikegami
Publication year - 2011
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.100714
Subject(s) - lactococcus lactis , casein , antibody , antibody response , ratón , endocrinology , chemistry , medicine , oral administration , biology , microbiology and biotechnology , andrology , immunology , biochemistry , bacteria , genetics , lactic acid
Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4(+)CD25(+) cells was increased in DO11.10 mice orally given OVA, but this increase of CD4(+)CD25(+) cells were suppressed in L. lactis-fed DO11.10 mice.

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