A Tolerance Gene for Prenylated Flavonoid Encodes a 26S Proteasome Regulatory Subunit inSophora flavescens | Zendy

Nobukazu Shitan | Zendy; Yoshihisa Kamimoto | Zendy; Shota Minami | Zendy; Mizuki Kubo | Zendy; Kozue Ito | Zendy; Masataka Moriyasu | Zendy; Kazufumi Yazaki | Zendy

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A Tolerance Gene for Prenylated Flavonoid Encodes a 26S Proteasome Regulatory Subunit inSophora flavescens

Author(s) -

Nobukazu Shitan,

Yoshihisa Kamimoto,

Shota Minami,

Mizuki Kubo,

Kozue Ito,

Masataka Moriyasu,

Kazufumi Yazaki

Publication year - 2011

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100665

Subject(s) - sophora flavescens , proteasome , protein subunit , yeast , flavonoid , cdna library , gene , complementary dna , biology , prenylation , biochemistry , genetics , enzyme , matrine , neuroscience , antioxidant

Yeast functional screening with a Sophora flavescens cDNA library was performed to identify the genes involved in the tolerant mechanism to the self-producing prenylated flavonoid sophoraflavanone G (SFG). One cDNA, which conferred SFG tolerance, encoded a regulatory particle triple-A ATPase 2 (SfRPT2), a member of the 26S proteasome subunit. The yeast transformant of SfRPT2 showed reduced SFG accumulation in the cells.

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