Novel Synthesis of Optically Active Bishomotyrosine Derivatives Using the Friedel-Crafts Reaction in Triflic Acid | Zendy

Yuta Murai | Zendy; Yasuyuki Hashidoko | Zendy; Makoto Hashimoto | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Novel Synthesis of Optically Active Bishomotyrosine Derivatives Using the Friedel-Crafts Reaction in Triflic Acid

Author(s) -

Yuta Murai,

Yasuyuki Hashidoko,

Makoto Hashimoto

Publication year - 2011

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100595

Subject(s) - triflic acid , optically active , friedel–crafts reaction , phenol , chemistry , organic chemistry , combinatorial chemistry , catalysis

We report here a novel synthesis of optically active bishomotyrosine. The bishomotyrosine skeleton was constructed by using a Friedel-Crafts reaction between phenol and optically active N-Tfa-Glu(Cl)-OMe in triflic acid under the mild condition. Reduction and subsequent deprotection then afforded bishomotyrosine derivatives without any loss of optical purity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research