Identification of a Spatio-Temporal Enhancer Element for the Alzheimer’sAmyloid Precursor Protein-Like-1Gene in the NematodeCaenorhabditis elegans | Zendy

Ryusuke Niwa | Zendy; Kazumasa Hada | Zendy

Open Access

Identification of a Spatio-Temporal Enhancer Element for the Alzheimer’sAmyloid Precursor Protein-Like-1Gene in the NematodeCaenorhabditis elegans

Author(s) -

Ryusuke Niwa,

Kazumasa Hada

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100450

Subject(s) - caenorhabditis elegans , enhancer , transcription factor , biology , transcription (linguistics) , nuclear receptor , response element , gene , microbiology and biotechnology , genetics , gene expression , promoter , linguistics , philosophy

During the larva-to-adult transition of the nematode Caenorhabditis elegans, expression of the Alzheimer's amyloid precursor protein-like gene, apl-1, is temporally regulated in seam cells. This regulation requires several transcription factors, including nuclear receptor NHR-25. Here we describe a critical cis-regulatory element of apl-1 transcription. The element is conserved among Caenorhabditis sister species and is similar to nuclear receptor binding consensus.

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