Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors | Zendy

Masao Yamasaki | Zendy; Ayako Mukai | Zendy; Masayo OHBA | Zendy; Yoshihiro Mine | Zendy; Yoichi Sakakibara | Zendy; Masahito Suiko | Zendy; Kazuhiro Morishita | Zendy; Kazuo Nishiyama | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors

Author(s) -

Masao Yamasaki,

Ayako Mukai,

Masayo OHBA,

Yoshihiro Mine,

Yoichi Sakakibara,

Masahito Suiko,

Kazuhiro Morishita,

Kazuo Nishiyama

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100359

Subject(s) - cytotoxic t cell , genistein , estrogen receptor , t cell leukemia , apoptosis , agonist , receptor , cancer research , estrogen , leukemia , biology , endocrinology , medicine , chemistry , immunology , cancer , biochemistry , breast cancer , in vitro

Adult T-cell leukemia (ATL) occurs in human T-lymphotropic virus type I-infected individuals and is endemic to the southwestern area of Kyushu in Japan. Here, we found that nM levels of genistein and 17β-estradiol had cytotoxic effects on ATL cells and activated caspase-3. The estrogen receptor antagonist ICI182780 negated the cytotoxic effect of genistein. In addition, G protein-coupled estrogen receptor agonist G-1 also had a cytotoxic effect on ATL cells. This is the first report suggesting that estrogen receptors are a molecular target for ATL therapy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research