Evaluation of an Edible Blue-Green Alga,Aphanothece sacrum, for Its Inhibitory Effect on Replication of Herpes Simplex Virus Type 2 and Influenza Virus Type A | Zendy

Fumie Ogura | Zendy; Kyoko Hayashi | Zendy; JungBum Lee | Zendy; Kenji Kanekiyo | Zendy; Toshimitsu Hayashi | Zendy

Open Access

Evaluation of an Edible Blue-Green Alga,Aphanothece sacrum, for Its Inhibitory Effect on Replication of Herpes Simplex Virus Type 2 and Influenza Virus Type A

Author(s) -

Fumie Ogura,

Kyoko Hayashi,

JungBum Lee,

Kenji Kanekiyo,

Toshimitsu Hayashi

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100336

Subject(s) - herpes simplex virus , biology , virus , virology , viral replication , microbiology and biotechnology , in vitro , biochemistry

A hot-water extract of Aphanothece sacrum, an edible aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A, H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.

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