A Yeast Bioassay for Androgenic and Anti-Androgenic Compounds Based on the NH2- and COOH-Terminal Interaction of Androgen Receptor | Zendy

Masahiro Ogawa | Zendy; Ryoichi Yamaji | Zendy; Takakazu Mitani | Zendy; Yohei Murata | Zendy; Motoyuki Nakao | Zendy; Naoki Harada | Zendy; Yoshihisa Nakano | Zendy; Hiroshi Inui | Zendy

Open Access

A Yeast Bioassay for Androgenic and Anti-Androgenic Compounds Based on the NH₂- and COOH-Terminal Interaction of Androgen Receptor

Author(s) -

Masahiro Ogawa,

Ryoichi Yamaji,

Takakazu Mitani,

Yohei Murata,

Motoyuki Nakao,

Naoki Harada,

Yoshihisa Nakano,

Hiroshi Inui

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100323

Subject(s) - bioassay , androgen receptor , yeast , androgen , chemistry , ligand binding assay , receptor , biology , biochemistry , genetics , hormone , prostate cancer , cancer

Androgenic compounds induce an interaction between the NH(2)- and COOH-terminal regions (N-C interaction) of androgen receptor (AR). We describe a rapid yeast bioassay for androgenic and anti-androgenic compounds based on androgen-dependent β-catenin-enhanced N-C interaction. The bioassay was also effective at detecting compounds that inhibit the N-C interaction in ways that do not involve binding to the ligand-binding domain.

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