Yogurt ContainingLactobacillus gasseriOLL 2716 (LG21 yogurt) Accelerated the Healing of Acetic Acid-Induced Gastric Ulcer in Rats | Zendy

Masayuki Uchida | Zendy; Kimiko Shimizu | Zendy; Keiko Kurakazu | Zendy

Open Access

Yogurt ContainingLactobacillus gasseriOLL 2716 (LG21 yogurt) Accelerated the Healing of Acetic Acid-Induced Gastric Ulcer in Rats

Author(s) -

Masayuki Uchida,

Kimiko Shimizu,

Keiko Kurakazu

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100287

Subject(s) - lactobacillus gasseri , lactobacillus , acetic acid , prostaglandin e2 , medicine , food science , prostaglandin , chemistry , gastroenterology , fermentation , biochemistry

We have reported that LG21 yogurt containing Lactobacillus gasseri OLL 2716 (LG21 yogurt) inhibits the formation of HCl-induced acute gastric lesions through the generation of prostaglandin E₂. This study aimed to determine the role of viable Lactobacillus in the healing of acetic acid-induced chronic gastric ulcer. LG21 yogurt or γ-ray radiated LG21 yogurt was administered orally twice a day for 10 d at a dose of 5 ml/kg. LG21 yogurt significantly accelerated the healing of the ulcer, but γ-ray radiated LG21 yogurt did not. However, both yogurts significantly inhibited HCl-induced gastric erosive lesions and enhanced the generation of gastric mucosal prostaglandin E₂. From the above results, it was found that viable bacteria are needed to accelerate the healing of chronic gastric ulcer, but not to inhibit gastric lesions.

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