Identification of Osteoclastic Factors in the Nuclear Envelope of Mature, Multinucleated Osteoclasts | Zendy

MinYoung Youn | Zendy; Sally FujiyamaNakamura | Zendy; Ichiro Takada | Zendy; Yuuki Imai | Zendy; Shigeaki Kato | Zendy

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Identification of Osteoclastic Factors in the Nuclear Envelope of Mature, Multinucleated Osteoclasts

Author(s) -

MinYoung Youn,

Sally FujiyamaNakamura,

Ichiro Takada,

Yuuki Imai,

Shigeaki Kato

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100280

Subject(s) - multinucleate , osteoclast , microbiology and biotechnology , envelope (radar) , identification (biology) , chemistry , biology , biochemistry , botany , in vitro , telecommunications , radar , computer science

Multinucleation is indispensable to the bone-resorbing activity of mature osteoclasts. Nevertheless, little is known about the regulatory networks among multi-nuclei in a single mature osteoclast. For this reason, we purified osteoclastic factors from the nuclear envelope by two-dimensional gel electrophoresis. Two annexin family proteins and ferritin light chain 1 protein were identified as osteoclastic candidates.

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