Extension of the Lifespan ofCaenorhabditis elegansby the Use of Electrolyzed Reduced Water | Zendy

Hanxu Yan | Zendy; Huaize Tian | Zendy; Tomoya Kinjo | Zendy; Takeki Hamasaki | Zendy; Kosuke Tomimatsu | Zendy; Noboru Nakamichi | Zendy; Kiichiro Teruya | Zendy; Shigeru Kabayama | Zendy; Sanetaka Shirahata | Zendy

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Extension of the Lifespan ofCaenorhabditis elegansby the Use of Electrolyzed Reduced Water

Author(s) -

Hanxu Yan,

Huaize Tian,

Tomoya Kinjo,

Takeki Hamasaki,

Kosuke Tomimatsu,

Noboru Nakamichi,

Kiichiro Teruya,

Shigeru Kabayama,

Sanetaka Shirahata

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100250

Subject(s) - ultrapure water , caenorhabditis elegans , reactive oxygen species , growth medium , paraquat , biology , food science , chemistry , biochemistry , bacteria , environmental engineering , environmental science , genetics , gene

Electrolyzed reduced water (ERW) has attracted much attention because of its therapeutic effects. In the present study, a new culture medium, which we designated Water medium, was developed to elucidate the effects of ERW on the lifespan of Caenorhabditis elegans. Wild-type C. elegans had a significantly shorter lifespan in Water medium than in conventional S medium. However, worms cultured in ERW-Water medium exhibited a significantly extended lifespan (from 11% to 41%) compared with worms cultured in ultrapure water-Water medium. There was no difference between the lifespans of worms cultured in ERW-S medium and ultrapure water-S medium. Nematodes cultured in ultrapure water-Water medium showed significantly higher levels of reactive oxygen species than those cultured in ultrapure water-S medium. Moreover, ERW-Water medium significantly reduced the ROS accumulation induced in the worms by paraquat, suggesting that ERW-Water medium extends the longevity of nematodes at least partly by scavenging ROS.

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