The Occurrence of Renin Inhibitor in Rice: Isolation, Identification, and Structure-Function Relationship | Zendy

Saori Takahashi | Zendy; Tetsuo Tokiwano | Zendy; Keishi Hata | Zendy; Ikuko Kodama | Zendy; Mika Hokari | Zendy; Nao Suzuki | Zendy; Yuko Yoshizawa | Zendy; Takeshi Gotoh | Zendy

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The Occurrence of Renin Inhibitor in Rice: Isolation, Identification, and Structure-Function Relationship

Author(s) -

Saori Takahashi,

Tetsuo Tokiwano,

Keishi Hata,

Ikuko Kodama,

Mika Hokari,

Nao Suzuki,

Yuko Yoshizawa,

Takeshi Gotoh

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100233

Subject(s) - linoleic acid , oleic acid , chemistry , renin–angiotensin system , biochemistry , fatty acid , renin inhibitor , enzyme , food science , biology , endocrinology , blood pressure

We found renin inhibitory activity in rice. The physico-chemical data on the isolated inhibitors were identical to those of oleic acid and linoleic acid. Oleic acid and linoleic acid competitively inhibited renin activity, with K(i) values of 15.8 and 19.8 microM respectively. Other unsaturated free fatty acids also inhibited renin activity, but saturated fatty acids had no effect on it.

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