Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1 | Zendy

Masataka Narukawa | Zendy; Kanako Koizumi | Zendy; Yusaku Iwasaki | Zendy; Kikue Kubota | Zendy; Tatsuo Watanabe | Zendy

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Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1

Author(s) -

Masataka Narukawa,

Kanako Koizumi,

Yusaku Iwasaki,

Kikue Kubota,

Tatsuo Watanabe

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100133

Subject(s) - transient receptor potential channel , trpv1 , hek 293 cells , chemistry , subfamily , agonist , allyl isothiocyanate , isothiocyanate , receptor , biochemistry , gene

We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.

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