Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea | Zendy

Yuh-Hwa Liu | Zendy; Wen-Chun WU | Zendy; Yeh-Lin Lu | Zendy; Ying-Jang Lai | Zendy; WenChi Hou | Zendy

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Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea

Author(s) -

Yuh-Hwa Liu,

Wen-Chun WU,

Yeh-Lin Lu,

Ying-Jang Lai,

WenChi Hou

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.100096

Subject(s) - antioxidant , inhibitory postsynaptic potential , amine oxidase , chemistry , amine gas treating , biochemistry , pharmacology , enzyme , biology , neuroscience , organic chemistry

Hydroxyurea (HU, NH(2)CONHOH), or hydroxycarbamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicarbazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 microM.

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