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On expected score of cellwise alignments
Author(s) -
Riho Klement,
Jüri Lember
Publication year - 2017
Publication title -
acta et commentationes universitatis tartuensis de mathematica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.276
H-Index - 6
eISSN - 2228-4699
pISSN - 1406-2283
DOI - 10.12697/acutm.2017.21.10
Subject(s) - alphabet , focus (optics) , mathematics , computer science , algorithm , rest (music) , combinatorics , medicine , physics , philosophy , linguistics , optics , cardiology
We consider certain suboptimal alignments of two independent i.i.d. random sequences from a finite alphabet A={1,..., K}, both sequences having length n. In particular, we focus on so-called cellwise alignments, where in the first step so many 1-s as possible are aligned. These aligned 1-s define cells and the rest of the alignment is defined so that the already existing alignment of 1-s remains unchanged. We show that as n grows, for any cellwise alignment, the average score of a cell tends to the expected score of a random cell, a.s. Moreover, we show that a large deviation inequality holds. The second part of the paper is devoted to calculating the expected score of certain cellwise alignment referred to as priority letter alignment. In this alignment, inside every cell first all 2-s are aligned. Then all 3-s are aligned, but in such way that the already existing alignment of 2-s remains unchanged. Then we continue with 4-s and so on. Although easy to describe, for K bigger than 3 the exact formula for expected score is not that straightforward to find. We present a recursive formula for calculating the expected score.

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