Protection Mechanisms of Non-malignant and Malignant Cells against Ionizing Radiation I. The Cytological Effects of 2-mercaptoethylamine on the Rat and Mouse Ascites Tumors | Zendy

Fumio Kawamura | Zendy; Jindo Kobayashi | Zendy

Open Access

Protection Mechanisms of Non-malignant and Malignant Cells against Ionizing Radiation I. The Cytological Effects of 2-mercaptoethylamine on the Rat and Mouse Ascites Tumors

Author(s) -

Fumio Kawamura,

Jindo Kobayashi

Publication year - 1964

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.5.166

Subject(s) - ascites , ionizing radiation , malignant cells , cancer research , sarcoma , tumor cells , pathology , medicine , chemistry , irradiation , cancer , physics , nuclear physics

The present study deals with cytological effects of 2-mercaptoethyl amine on the Yoshida-sarcoma, the MTK-sarcoma III and Ehrlich ascites tumor concentrating a special attention on cell growth of tumor. 2-Mercaptoethylamine exerts influence upon tumor cells in process of mitosis, especially on an increase of mitotic cells, leading to increase of prophasic cells at first and metaphasic cells secondarily. The protection mechanism against radiation exerted by 2-merca ptoethylamine indicated that this drug induced an increase of mitotic activity. This increase of mitotic activity might be interpreted as a protecting effect against radiation injury.

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