Induced Transgenerational Genetic Effects in Rodents and Humans | Zendy

A.T. Natarajan | Zendy

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Induced Transgenerational Genetic Effects in Rodents and Humans

Author(s) -

A.T. Natarajan

Publication year - 2006

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.47.b39

Subject(s) - transgenerational epigenetics , biology , genetics , ionizing radiation , physiology , gene , epigenetics , irradiation , physics , nuclear physics

Delayed appearance of induced mutations has been observed in Drosophila, plants, rodents and recently in humans. The significance of this phenomenon is now recognized especially after the pioneering work of Nomura demonstrating transgenerational tumour induction in mice following treatment with urethane or ionizing radiation. A brief review of the literature on transgenerational genetic effects, namely, chromosomal aberrations and mutations, in rodents and humans is presented here.

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