Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions | Zendy

Tetsuya Kawata | Zendy; Hisao Ito | Zendy; Ken Motoori | Zendy; Takuya Ueda | Zendy; Naoyuki Shigematsu | Zendy; Yoshiya Furusawa | Zendy; Marco Durante | Zendy; K. George | Zendy; Honglu Wu | Zendy; Francis A. Cucinotta | Zendy

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Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions

Author(s) -

Tetsuya Kawata,

Hisao Ito,

Ken Motoori,

Takuya Ueda,

Naoyuki Shigematsu,

Yoshiya Furusawa,

Marco Durante,

K. George,

Honglu Wu,

Francis A. Cucinotta

Publication year - 2002

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.43.s169

Subject(s) - chromatid , chromatin , biophysics , chemistry , biology , biochemistry , dna , chromosome , gene

The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

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