Open AccessCan Gene Therapy Overcome the Problem of Hypoxia in Radiotherapy?
Author(s) -
Olga Greco,
Adam V. Patterson,
Gabi U. Dachs
Publication year - 2000
Publication title -
journal of radiation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 60
eISSN - 1349-9157
pISSN - 0449-3060
DOI - 10.1269/jrr.41.201
Subject(s) - radiation therapy , hypoxia (environmental) , genetic enhancement , computational biology , medicine , gene , chemistry , biology , genetics , oxygen , organic chemistry
Studies have shown that reduced oxygen tension (hypoxia) in solid tumours adversely affects the outcome of radiotherapy. Despite being an independent prognostic marker of poor treatment outcome, hypoxia represents a physiological difference that can be utilised for selective cancer treatment. Since severe hypoxia (pO2<0.3%; 2.5 mmHg) does not occur in normal tissue, it may be exploited for therape...