Improvement of Accuracy of Chromosome Aberration Analysis for Biological Radiation Dosimetry | Zendy

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Improvement of Accuracy of Chromosome Aberration Analysis for Biological Radiation Dosimetry

Author(s) -

Reiko Kanda

Publication year - 2000

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.41.1

Subject(s) - chromosome aberration , chromosome , dosimetry , chromosomal translocation , radiosensitivity , biodosimetry , chromosome analysis , radiation , medical physics , nuclear medicine , biology , genetics , medicine , optics , ionizing radiation , karyotype , irradiation , physics , radiation therapy , radiology , gene , nuclear physics

The frequency of chromosome aberrations in circulating lymphocytes is accepted as being the most reliable indicator of the absorbed dose of radiation. Researches done to improve the accuracy of cytogenetic analysis are described in this review. These include investigations of in vitro factors that affect the yield of radiation-induced aberrations and of in vivo factors that affect the chromosomal radiosensitivity of individuals. Improved chromosome-painting methods for accurate judgment of dicentrics and translocations are introduced. The practicality of these advanced cytogenetic techniques is shown by examinations of individuals exposed in the radiation accident at Tokaimura in 1999.

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