RBE-LET Relationships in Mutagenesis by Ionizing Radiation. | Zendy

Hooshang Nikjoo | Zendy; R.J. Munson | Zendy; B.A. Bridges | Zendy

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RBE-LET Relationships in Mutagenesis by Ionizing Radiation.

Author(s) -

Hooshang Nikjoo,

R.J. Munson,

B.A. Bridges

Publication year - 1999

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.40.s85

Subject(s) - ionizing radiation , mutagenesis , relative biological effectiveness , biology , linear energy transfer , mutation , drosophila melanogaster , escherichia coli , genetics , allele , radiation , irradiation , physics , gene , quantum mechanics , nuclear physics

The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and Drosophila melanogaster. Experimental data are presented for the relative biological effectiveness of helium ions and alpha-particles for mutation induction and genome lethality in Escherichia coli. The paper examines the relationship between the mutational events and LET. The RBE-LET values for T4 phage, E. coli WP2 and mwh (multiple wing hair) show dependency on LET while the wi (white-ivory) allele mutants show no dependency.

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