Open AccessEffect of Ionizing Radiation on the Differentiation of ROS 17/2.8 Osteoblasts through Free Radicals
Author(s) -
HanJung Chae,
SooWan Chae,
Jang–Sook Kang,
Byung-Gwan Bang,
Jo-Il Han,
SunRock Moon,
Raekil Park,
HongSeob So,
KEUN-SOO JEE,
Hyungmin Kim,
HyungRyong Kim
Publication year - 1999
Publication title -
journal of radiation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 60
eISSN - 1349-9157
pISSN - 0449-3060
DOI - 10.1269/jrr.40.323
Subject(s) - ionizing radiation , chemistry , reactive oxygen species , radical , kinase , osteoblast , biophysics , radiation , microbiology and biotechnology , irradiation , biochemistry , in vitro , biology , physics , quantum mechanics , nuclear physics
Although the acceleration of bone regeneration by radiation has been reported, the mechanisms of action of radiation on bone are unclear. The present results indicate that ionizing radiation-stimulated differentiation could result from the generation of reactive oxygen species during radiation exposure. The free radical release is considered as the most important mechanism of bone effect by radiation treatment. In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. The JNK and AP-1 activation is mediated with radiation-released free radicals in ROS 17/2.8 osteoblasts. These results indicate that ionizing radiation at a single dose of up to 5 Gray stimulates differentiation of ROS 17/2.8 osteoblasts via free radial release which may affect JNK/SAPK and AP-1 activities.
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