Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues. | Zendy

Riichi Tawa | Zendy; Yutaka Kimura | Zendy; Junichiro Komura | Zendy; Yoshinori Miyamura | Zendy; Akihiro Kurishita | Zendy; Masao S. Sasaki | Zendy; Hiromu Sakurai | Zendy; Tetsuya Ono | Zendy

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Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues.

Author(s) -

Riichi Tawa,

Yutaka Kimura,

Junichiro Komura,

Yoshinori Miyamura,

Akihiro Kurishita,

Masao S. Sasaki,

Hiromu Sakurai,

Tetsuya Ono

Publication year - 1998

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.39.271

Subject(s) - spleen , ionizing radiation , dna methylation , genomic dna , irradiation , methylation , dna , microbiology and biotechnology , biology , x ray , chemistry , gene , biochemistry , gene expression , immunology , nuclear physics , quantum mechanics , physics

Effects of ionizing radiation on the level of genomic DNA methylation in liver, brain and spleen of mouse as well as in two kinds of cultured cells were examined by high-performance liquid chromatography. Ten Gy of whole body X-radiation reduced the 5-methyldeoxycytidine contents by about 40% within 8 hours after irradiation in liver. Similar effects were observed at 4 or 7 Gy of X-ray irradiation. However, no such change was detected in brain, spleen and cultured cells. The data indicate that radiation-induced alteration in genomic DNA methylation is not ubiquitous among different tissues and cells.

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