Changes in Serum Ceruloplasmin Activity after Whole Body Irradiation of Mammals. | Zendy

ENIO ALADJOV | Zendy; Tatyana Vlaykova | Zendy

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Changes in Serum Ceruloplasmin Activity after Whole Body Irradiation of Mammals.

Author(s) -

ENIO ALADJOV,

Tatyana Vlaykova

Publication year - 1997

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.38.157

Subject(s) - ceruloplasmin , guinea pig , irradiation , oxidase test , chemistry , medicine , endocrinology , biology , enzyme , biochemistry , physics , nuclear physics

Chronological changes in ceruloplasmin oxidase activity after gamma-irradiation with semilethal doses of 3-5 Gy, were investigated in four mammalian species; rat, guinea pig, lamb and pig. The ceruloplasmin activity increased soon after irradiation but later decreased. Although the extent of the increase and its time-course varied among species, it was most remarkable in rats and least so in guinea pigs, with the highest activity generally attained at 12 h after irradiation. In contrast, erythrocyte and leukocyte counts decreased after irradiation, and showed minimum values when ceruloplasmin levels were maximum. These results suggest that ceruloplasmin is involved in the recovery from radiation disease.

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