Differences in heavy-ion-induced DNA double-strand breaks in a mouse DNA repair-deficient mutant cell line (SL3-147) before and after chromatin proteolysis. | Zendy

Masahiro Murakami | Zendy; Kiyomi EguchiKasai | Zendy; Koki Sato | Zendy; Shinichi Minohara | Zendy; Fumio Yatagai | Zendy; TATSUAKI KANAI | Zendy

Open Access

Differences in heavy-ion-induced DNA double-strand breaks in a mouse DNA repair-deficient mutant cell line (SL3-147) before and after chromatin proteolysis.

Author(s) -

Masahiro Murakami,

Kiyomi EguchiKasai,

Koki Sato,

Shinichi Minohara,

Fumio Yatagai,

TATSUAKI KANAI

Publication year - 1995

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.36.258

Subject(s) - chromatin , dna , double strand , dna repair , microbiology and biotechnology , dna damage , mutant , ionizing radiation , irradiation , chemistry , biophysics , biology , biochemistry , physics , gene , nuclear physics

DNA double-strand breaks induced by X- or neon beam-irradiation in a DNA double-strand break-repair-deficient mutant cell line (SL3-147) were examined. The increase in the number of DNA double-strand breaks was dose depend after irradiation with X-rays and neon beams and was enhanced by chromatin-proteolysis treatment before irradiation. These results suggest that the induction of DNA double-strand breaks by ionizing radiation, including heavy-ions, is influenced by the chromatin structure.

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