Evaluation of Radioprotective Action of a Mutant (E-25) Form of Chlorella vulgaris in Mice. | Zendy

Lakshmi Sarma | Zendy; Ashu Bhan Tiku | Zendy; P.C. Kesavan | Zendy; Masahiro Ogaki | Zendy

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Evaluation of Radioprotective Action of a Mutant (E-25) Form of Chlorella vulgaris in Mice.

Author(s) -

Lakshmi Sarma,

Ashu Bhan Tiku,

P.C. Kesavan,

Masahiro Ogaki

Publication year - 1993

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.34.277

Subject(s) - chlorella vulgaris , body weight , micronucleus test , pharmacology , chlorella , micronucleus , irradiation , mutant , gamma irradiation , chemistry , zoology , medicine , physiology , biology , toxicity , botany , biochemistry , gene , nuclear physics , algae , physics

The possible role of orally fed Chlorella vulgaris (E-25) in modulating the gamma-ray induced chromosomal damage in whole-body irradiated mice was evaluated using a micronucleus test. Different doses of E-25 were administered either chronically (once, twice or thrice a day for 28 days) or as single acute doses before/after irradiation. A significant radioprotective effect was observed in both acute and chronic pretreatments, but only at doses above 400 mg/kg body weight. However, in mice that received E-25 (500 mg/kg) three times a day for 28 days, there was no protective effect, and a significant loss in their body weight was observed. Interestingly, E-25 afforded significant radioprotection even when it was administered within 0.4 hr after irradiation.

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