Formation of 2,5-Diamino-4-Hydroxy-6(2'-Deoxyribosyl)-Formamidopyrimidine from 2'-deoxyguanosine in Aqueous Solution Irradiated with 60Co Gamma-Rays. | Zendy

Mohsin Ali | Zendy; Osamu Yamamoto | Zendy

Open Access

Formation of 2,5-Diamino-4-Hydroxy-6(2'-Deoxyribosyl)-Formamidopyrimidine from 2'-deoxyguanosine in Aqueous Solution Irradiated with 60Co Gamma-Rays.

Author(s) -

Mohsin Ali,

Osamu Yamamoto

Publication year - 1993

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.34.12

Subject(s) - chemistry , deoxyguanosine , aqueous solution , yield (engineering) , irradiation , radiolysis , high performance liquid chromatography , ultraviolet , chromatography , nuclear chemistry , organic chemistry , adduct , materials science , physics , quantum mechanics , nuclear physics , metallurgy

2'-Deoxyguanosine in aqueous solution (5 x 10(-4) mol/dm3) was irradiated with 60Co gamma-rays under N2O. Products were separated by gel chromatography (Cellulofine GC-15-m) and high performance liquid chromatography (Inertsil ODS-2). 2-Amino-4-hydroxy-5-formamido-6-(2'-deoxyribosyl)-aminopyrimidine was one of the main radiolytic products. The formation of 2,5-diamino-4- hydroxy-6-(2'-deoxyribosyl)-formamidopyrimidine was detected, this compound being verified by measuring its ultraviolet absorption spectrum and analyzing its trimethylsilylated derivative by gas chromato-mass spectrometry. Its yield in terms of 2-amino-4-hydroxy-5-formamido-6-(2'-deoxyribosyl)- aminopyrimidine was 1:3.

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