Heterogeneity of the Radiosensitivity and Origins of Tissue Macrophage Colony-Forming Cells. | Zendy

Yoichi Oghiso | Zendy; Yutaka Yamada | Zendy

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Heterogeneity of the Radiosensitivity and Origins of Tissue Macrophage Colony-Forming Cells.

Author(s) -

Yoichi Oghiso,

Yutaka Yamada

Publication year - 1992

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.33.334

Subject(s) - macrophage , haematopoiesis , spleen , bone marrow , radioresistance , radiosensitivity , biology , alveolar macrophage , immunology , pathology , stem cell , microbiology and biotechnology , medicine , cell culture , biochemistry , in vitro , genetics , radiation therapy

Previous studies suggest that the radiosensitivity and origin of tissue macrophage precursors differ from those of hemopoietic macrophage colony-forming units (CFU-Ms) committed to macrophage-lineage cells. We assessed the origins of tissue macrophage colony-forming cells (M-CFCs) in mice by comparing their kinetics and radiosensitivities in the normal steady state and under the conditions of bone marrow depletion by 89Sr-administration and/or splenectomy. The results indicate that the radiosensitive peritoneal M-CFCs elicited by thioglycollate are derived from bone marrow macrophage precursors; where as alveolar M-CFCs, which are radioresistant, are self-sustained locally and independent of hemopoietic macrophage precursors. In contrast, highly radiosensitive liver M-CFCs are probably derived from CFU-Ms that appear to be propagated in the spleen in association with hemopoietic responses.

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