A Device for In Vitro Irradiation with .ALPHA.-Particles Using an .ALPHA.-Emitting Radioactive Source. | Zendy

Nobuhito Ishigure | Zendy; Takashi Nakano | Zendy; Hiroko Enomoto | Zendy

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A Device for In Vitro Irradiation with .ALPHA.-Particles Using an .ALPHA.-Emitting Radioactive Source.

Author(s) -

Nobuhito Ishigure,

Takashi Nakano,

Hiroko Enomoto

Publication year - 1991

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.32.404

Subject(s) - alpha particle , irradiation , fluence , materials science , radiochemistry , layer (electronics) , monolayer , alpha (finance) , α particles , radioactive source , chemistry , atomic physics , physics , optics , nanotechnology , nuclear physics , medicine , construct validity , nursing , detector , patient satisfaction

A device to irradiate a monolayer of cultured cells with alpha-particles using an Am-241 alpha-source (33.4 MBq) was designed to investigate RBEs of alpha-particles in cell killing, induction of chromosome aberration, mutagenic changes and transformation. This device can be used conveniently in a common laboratory by a small number of researchers without any limitation of machine time. The device performs as follows: (1) The energy of alpha-particles at the entrance of the cell layer is 3.20 MeV with a standard deviation of 0.25 MeV, (2) the incident angle to the cell layer is 82.8 degrees with a standard deviation of 3.2 degrees, (3) the fluence rate is 4.7 x 10(5) cm-2.min-1, (4) the average LET infinity for a cell layer 5 microns thick is 138 keV/micron, (5) the average dose rate for a cell layer 5 microns thick is 0.10 Gy/min., (6) a temperature and CO2 concentration conducive to cell cultivation are maintained during irradiation.

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