Effects of 3'-deoxyadenosine (cordycepin) on the repair of X-ray-induced DNA single- and double-strand breaks in Chinese hamster V79 cells. | Zendy

Wakako Hiraoka | Zendy; Mikinori Kuwabara | Zendy; Fumiaki Sato | Zendy

Open Access

Effects of 3'-deoxyadenosine (cordycepin) on the repair of X-ray-induced DNA single- and double-strand breaks in Chinese hamster V79 cells.

Author(s) -

Wakako Hiraoka,

Mikinori Kuwabara,

Fumiaki Sato

Publication year - 1990

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.31.156

Subject(s) - cordycepin , chinese hamster , double strand , deoxyadenosine , dna , dna repair , microbiology and biotechnology , dna damage , chemistry , biology , biochemistry

The ability of cordycepin to inhibit the repair of DNA strand breaks was examined with X-irradiated Chinese hamster V79 cells in log-phase culture. A filter elution technique revealed that 70 microM cordycepin did not inhibit the repair of single-strand breaks but inhibited the repair of double-strand breaks. These findings confirmed the fact that the increase in the lethality of cordycepin in X-irradiated cultured mammalian cells was attributable to unrepaired DNA double-strand breaks.

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