Resistance of STS/A mice to lymphoma induction by X-irradiation. | Zendy

Masaaki Okumoto | Zendy; Ryosuke Nishikawa | Zendy; Shunsuke Imai | Zendy; J. Hilgers | Zendy

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Resistance of STS/A mice to lymphoma induction by X-irradiation.

Author(s) -

Masaaki Okumoto,

Ryosuke Nishikawa,

Shunsuke Imai,

J. Hilgers

Publication year - 1989

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.30.135

Subject(s) - incidence (geometry) , lymphoma , biology , strain (injury) , significant difference , pathology , immunology , medicine , anatomy , physics , optics

While fractionated X-irradiation induced a high incidence lymphomas in BALB/cHeA mice (77% in females and 86% in males), it induced the disease at an extremely low incidence in STS/A mice (8% in females and 9% in males). The latent period of lymphoma development was short in BALB/cHeA mice, but relatively long in STS/A mice. No significant difference of incidence of the disease between sexes in either strain was observed. F1 hybrid mice showed an intermediate incidence of radiation-induced lymphomas. This suggests that neither resistance of STS/A mice nor susceptibility of BALB/cHeA mice to radiogenic lymphomas is dominant.

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