Influence of Ovariotomy on Recovery of Thymus Following X-ray Irradiation in ICR/JCL Mice | Zendy

S. Takizawa | Zendy; Yutaka Naito | Zendy; Shogo Inoue | Zendy

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Influence of Ovariotomy on Recovery of Thymus Following X-ray Irradiation in ICR/JCL Mice

Author(s) -

S. Takizawa,

Yutaka Naito,

Shogo Inoue

Publication year - 1974

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.15.197

Subject(s) - lymphopoiesis , bone marrow , regeneration (biology) , stem cell , lymphatic system , biology , hormone , haematopoiesis , endocrinology , medicine , pathology , microbiology and biotechnology , immunology

Ovariotomy in 8 week-old, specific pathogen free ICR/JCL mice was effective in securing a marked thymus regeneration following a single whole body irradiation with 300 rads of X-ray. Recovery of the bone marrow cell counts, especially of the lymphoid cells, preceded the thymus regeneration and was more marked in spayed mice than in the sham-operated. On the basis of these results, it is suggested that ovarian hormones play a role in the thymic lymphopoiesis by affecting the dynamics of the lymphoid stem cells in the bone marrow and/or the lymphopoietic microenvironments in the thymic cortex.

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