Studies on Photodynamic Action. I. The Action on Pneumococcal Transforming DNA | Zendy

Hitoshi Fujita | Zendy; Etsuko Saito | Zendy; Kenshi Suzuki | Zendy; Akiyoshi Wada | Zendy

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Studies on Photodynamic Action. I. The Action on Pneumococcal Transforming DNA

Author(s) -

Hitoshi Fujita,

Etsuko Saito,

Kenshi Suzuki,

Akiyoshi Wada

Publication year - 1970

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.11.1

Subject(s) - dna , action spectrum , chemistry , photochemistry , visible spectrum , biophysics , biochemistry , biology , physics , optics

The effect of illumination with visible light in the presence of dye on pneumococcal transforming DNA was investigated and the following results were obtained. (1) The DNA was inactivated under oxygenated condition. (2) The dye bound to DNA was exclusively involved in the inactivation process. This conclusion was derived from the following findings: (a) The action spectrum for the inactivation was consistent with the absorption spectrum of the bound dye rather than that of free dye. (b) The initial rate constant of inactivation ran parallel with the amount of bound dye. (3) The length of illuminated DNA was reduced as revealed by the increase in rotary diffusion constant.

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