Gene Expression Associated with DNA-Dependent Protein Kinase Activity under Normoxia, Hypoxia, and Reoxygenation | Zendy

Tadashi Tsuchimoto | Zendy; Kohichi Sakata | Zendy; Masanori Someya | Zendy; Hiroyuki Yamamoto | Zendy; Ryoichi Hirayama | Zendy; Yoshihisa Matsumoto | Zendy; Yoshiya Furusawa | Zendy; Masato Hareyama | Zendy

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Gene Expression Associated with DNA-Dependent Protein Kinase Activity under Normoxia, Hypoxia, and Reoxygenation

Author(s) -

Tadashi Tsuchimoto,

Kohichi Sakata,

Masanori Someya,

Hiroyuki Yamamoto,

Ryoichi Hirayama,

Yoshihisa Matsumoto,

Yoshiya Furusawa,

Masato Hareyama

Publication year - 2011

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.10137

Subject(s) - gene , gene expression , dna , microbiology and biotechnology , biology , hypoxia (environmental) , regulation of gene expression , dna damage , chemistry , biochemistry , organic chemistry , oxygen

In order to elucidate the mechanism of concerted expression of various proteins related to DNA-PK activity, we examined the relationship of the expression of these proteins with that of a transcription factor Sp1. We also explored whether the expression of genes related to DNA-PK activity and Sp1 changed after hypoxia and reoxygenation. RT-PCR was employed to measure expression of various proteins...

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