The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice | Zendy

Liren Qian | Zendy; Fei Cao | Zendy; Jianguo Cui | Zendy; Yicun Wang | Zendy; Yuecheng Huang | Zendy; Yunhai Chuai | Zendy; Luqian ZAHO | Zendy; Hao Jiang | Zendy; Jianming Cai | Zendy

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The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice

Author(s) -

Liren Qian,

Fei Cao,

Jianguo Cui,

Yicun Wang,

Yuecheng Huang,

Yunhai Chuai,

Luqian ZAHO,

Hao Jiang,

Jianming Cai

Publication year - 2010

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.10093

Subject(s) - ionizing radiation , malondialdehyde , in vivo , chemistry , radical , cardioprotection , irradiation , hydrogen , endogeny , biophysics , hydroxyl radical , antioxidant , hydrogen peroxide , oxidative stress , pharmacology , biochemistry , medicine , biology , ischemia , physics , microbiology and biotechnology , organic chemistry , nuclear physics

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.

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