Effect of Protein Synthesis Inhibitor on Accumulation of Fructose-1, 6-diphosphate in Irradiated Rat Thymocytes | Zendy

Harumi Ohyama | Zendy; Takeshi Yamada | Zendy

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Effect of Protein Synthesis Inhibitor on Accumulation of Fructose-1, 6-diphosphate in Irradiated Rat Thymocytes

Author(s) -

Harumi Ohyama,

Takeshi Yamada

Publication year - 1969

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.10.165

Subject(s) - cycloheximide , phosphofructokinase , fructose , chemistry , irradiation , biochemistry , protein biosynthesis , enzyme , glycolysis , physics , nuclear physics

It has been already shown that ionizing radiation brings about the enhancement of phosphofructokinase reaction in rat thymocytes and a consequent accumulation of fructose-1, 6-diphosphate. Protein synthesis inhibitor, such as cycloheximide was shown to have no effect on this accumulation. Explanation of fructose-1, 6-diphosphate accumulation in terms of the stimulated de novo synthesis of phosphofructokinase could be, therefore, ruled out.

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