Effect of Whole-body X-irradiation on the Microsomal Drug-metabolizing Enzyme System in Rat Liver | Zendy

SHOGO ICHII | Zendy; Nagasumi Yago | Zendy; Shigeru Kobayashi | Zendy; Saburo Omata | Zendy

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Effect of Whole-body X-irradiation on the Microsomal Drug-metabolizing Enzyme System in Rat Liver

Author(s) -

SHOGO ICHII,

Nagasumi Yago,

Shigeru Kobayashi,

Saburo Omata

Publication year - 1969

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.10.1

Subject(s) - demethylase , microsome , adrenalectomy , cytochrome p450 , endocrinology , chemistry , enzyme inducer , enzyme , medicine , cytochrome , whole body irradiation , irradiation , drug metabolism , biology , biochemistry , bone marrow , epigenetics , physics , nuclear physics , gene

Aminopyrine N-demethylase activity in rat hepatic microsomes decreased significantly after whole-body X-irradiation of 500 and 650 R. Process of the phenobarbiturate-induction of aminopyrine N-demethylase was found to be inhibited during quite an early period of the induction. Adrenalectomy caused marked decreases in the enzyme activity and cytochrome P-450 content of hepatic microsomes. Physiological significance of these and other metabolic changes was discussed in relation to the lethality of acutely irradiated animals.

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