Current Topics in DNA Double-Strand Break Repair | Zendy

Junya Kobayashi | Zendy; Kuniyoshi Iwabuchi | Zendy; Kiyoshi Miyagawa | Zendy; Eiichiro Sonoda | Zendy; Keiji Suzuki | Zendy; Minoru Takata | Zendy; Hiroshi Tauchi | Zendy

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Current Topics in DNA Double-Strand Break Repair

Author(s) -

Junya Kobayashi,

Kuniyoshi Iwabuchi,

Kiyoshi Miyagawa,

Eiichiro Sonoda,

Keiji Suzuki,

Minoru Takata,

Hiroshi Tauchi

Publication year - 2008

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.07130

Subject(s) - homologous recombination , dna repair , homologous chromosome , double strand , dna , histone , function (biology) , dna damage , microbiology and biotechnology , biology , genetics , computational biology , gene

DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.

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