Open AccessFullerenol C60(OH)24 Effects on Antioxidative Enzymes Activity in Irradiated Human Erythroleukemia Cell Line
Author(s) -
Višnja Bogdanović,
Karmen Stankov,
Ivana Ičević,
D. Žikić,
Aleksandra Nikolić,
Slavica Šolajić,
Aleksandar Djordjević,
Gordana Bogdanović
Publication year - 2008
Publication title -
journal of radiation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 60
eISSN - 1349-9157
pISSN - 0449-3060
DOI - 10.1269/jrr.07092
Subject(s) - superoxide dismutase , reactive oxygen species , chemistry , oxidative stress , ionizing radiation , glutathione peroxidase , in vivo , cell culture , in vitro , enzyme , radiosensitivity , glutathione , biochemistry , reactive nitrogen species , irradiation , biology , physics , microbiology and biotechnology , genetics , nuclear physics
Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pre-treatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismutase and glutathione peroxidase in irradiated K562 cells.
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