Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries | Zendy

Jian-Ming Lü | Zendy; Jacobo Nurko | Zendy; Jun Jiang | Zendy; Sarah M. Weakley | Zendy; Peter H. Lin | Zendy; Qizhi Yao | Zendy; Changyi Chen | Zendy

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Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries

Author(s) -

Jian-Ming Lü,

Jacobo Nurko,

Jun Jiang,

Sarah M. Weakley,

Peter H. Lin,

Qizhi Yao,

Changyi Chen

Publication year - 2011

Publication title -

medical science monitor

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.636

H-Index - 85

eISSN - 1643-3750

pISSN - 1234-1010

DOI - 10.12659/msm.882040

Subject(s) - nordihydroguaiaretic acid , enos , pharmacology , endothelial dysfunction , ritonavir , medicine , endothelium , oxidative stress , chemistry , nitric oxide , glutathione , nitric oxide synthase , biochemistry , immunology , enzyme , lipoxygenase , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy

HIV infection and treatment with highly active antiretroviral therapy (HAART) including HIV protease inhibitor ritonavir (RTV) have been associated with endothelial dysfunction and cardiovascular disease including pulmonary arterial hypertension. The objective of this study was to determine if nordihydroguaiaretic acid (NDGA), a natural herbal antioxidant found in the creosote bush Larrea tridentate, can protect vascular tissues against RTV-induced vascular injury.

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