Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells | Zendy

Sarah M. Weakley | Zendy; Jun Jiang | Zendy; Jinhu Lü | Zendy; Xinwen Wang | Zendy; Peter H. Lin | Zendy; Qizhi Yao | Zendy; Changyi Chen | Zendy

Open Access

Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells

Author(s) -

Sarah M. Weakley,

Jun Jiang,

Jinhu Lü,

Xinwen Wang,

Peter H. Lin,

Qizhi Yao,

Changyi Chen

Publication year - 2011

Publication title -

medical science monitor

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.636

H-Index - 85

eISSN - 1643-3750

pISSN - 1234-1010

DOI - 10.12659/msm.881926

Subject(s) - oxidative stress , antioxidant , pharmacology , ritonavir , reactive oxygen species , medicine , glutathione , enos , endothelial dysfunction , nitric oxide , endothelium , chemistry , biochemistry , nitric oxide synthase , immunology , enzyme , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy

Patients with HIV have an increased incidence of pulmonary artery hypertension. This study was designed to determine if the naturally occurring antioxidant dihydroxybenzyl alcohol (DHBA) could counteract the deleterious effects of ritonavir (RTV), an HIV-protease inhibitor known to impair endothelial function and increase oxidative stress.

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