Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5 | Zendy

Shaquria Adderley | Zendy; Kelly Thuet | Zendy; Meera Sridharan | Zendy; Elizabeth Bowles | Zendy; Alan H. Stephenson | Zendy; Mary L. Ellsworth | Zendy; Randy S. Sprague | Zendy

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Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5

Author(s) -

Shaquria Adderley,

Kelly Thuet,

Meera Sridharan,

Elizabeth Bowles,

Alan H. Stephenson,

Mary L. Ellsworth,

Randy S. Sprague

Publication year - 2011

Publication title -

medical science monitor

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.636

H-Index - 85

eISSN - 1643-3750

pISSN - 1234-1010

DOI - 10.12659/msm.881763

Subject(s) - cytosol , phosphodiesterase , identification (biology) , cgmp specific phosphodiesterase type 5 , chemistry , biology , microbiology and biotechnology , biochemistry , computational biology , enzyme , anatomy , botany , sildenafil

Within erythrocytes (RBCs), cAMP levels are regulated by phosphodiesterases (PDEs). Increases in cAMP and ATP release associated with activation of β-adrenergic receptors (βARs) and prostacyclin receptors (IPRs) are regulated by PDEs 2, 4 and PDE 3, respectively. Here we establish the presence of cytosolic PDEs in RBCs and determine a role for PDE5 in regulating levels of cGMP.

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